G-protein diseases furnish a model for the turn-on switch.

doi:10.1038/27831

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Article

G-protein diseases furnish a model for the turn-on switch.

Nature - 2 Jul 1998

Iiri T, Farfel Z, Bourne H R

Abstract excerpt

How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal s...

Topics

GTP-Binding Proteins
Guanosine Diphosphate
Guanosine Triphosphate
Humans
Models, Biological
Models, Molecular
Mutation
Protein Conformation
Receptors, Cell Surface

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