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Article

G-protein diseases furnish a model for the turn-on switch.

Nature - 2 Jul 1998

Iiri T, Farfel Z, Bourne H R

Abstract excerpt

How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal structures and results from biochemical experiments, the phenotypes produced by these mutations suggest a model for the...

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PMID: 9665125
DOI: 10.1038/27831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expanding horizons for receptors coupled to G proteins: diversity and disease.Semantic proximity Read ↗

G protein-coupled receptors: abnormalities in signal transmission, disease states and pharmacotherapy.Semantic proximity Read ↗

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Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.Semantic proximity Read ↗

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