Article
Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme.
The Journal of clinical investigation - 15 Jul 1998
Ramaraj P, Kessler S P, Colmenares C, Sen G C
Abstract excerpt
Although angiotensin-converting enzyme (ACE) has been studied primarily in the context of its role in blood pressure regulation, this widely distributed enzyme has many other physiological functions. The ACE gene encodes two isozymes. The somatic isozyme is expressed in many tissues, including va...
Topics
- Animals
- Female
- Fertility
- Gene Expression
- Humans
- Infertility, Male
- Isoenzymes
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Peptidyl-Dipeptidase A
- Phenotype
- Rabbits
- Spermatozoa
- Testis
- Transgenes