Article
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013
Fujihara Yoshitaka, Tokuhiro Keizo, Muro Yuko, Kondoh Gen, Araki Yoshihiko, Ikawa Masahito, Okabe Masaru
Abstract excerpt
Formation of spermatozoa of normal shape, number, and motility is insufficient for the male siring of pups. The spermatozoa must be accompanied by sound fertilizing ability. We found that males with disrupted testis-expressed gene 101 (Tex101) produce normal-looking but fertilization-incompetent spermatozoa, which were accompanied by a deficiency of a disintegrin and metallopeptidase domain 3 (ADAM3) on sperm...
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