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Article

Characterization of T and B cell repertoire diversity in patients with RAG deficiency

17 Dec 2016

Abstract excerpt

= 4). Restriction of repertoire diversity skewed usage of variable (V), diversity (D), and joining (J) segment genes, and abnormalities of CDR3 length distribution were progressively more prominent in patients with a more severe phenotype. Skewed usage of V, D, and J segment genes was present also within unique sequences, indicating a primary restriction of repertoire. Patients with Omenn syndrome had a high...

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PMID: 28783691
DOI: 10.1126/sciimmunol.aah6109

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