Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).

1 Apr 1991

Abstract excerpt

We report the immunological characteristics of five patients with Omenn's syndrome, a rare inherited immunodeficiency also known as combined immunodeficiency with hypereosinophilia. The syndrome is characterized by T cell infiltration of skin, gut, liver, and spleen leading to diffuse erythroderma, protracted diarrhea, failure to thrive, and hepatosplenomegaly. Blood T cells as well as those infiltrating the skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Diaphragmatic Hernia Studies
Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2010548
DOI: 10.1172/jci115139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).PMID 2010548Read ↗

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.Semantic proximity Read ↗

Omenn syndrome does not live by V(D)J recombination alone.Semantic proximity Read ↗

Omenn syndrome: inflammation in leaky severe combined immunodeficiency.Semantic proximity Read ↗

Intrathymic restriction and peripheral expansion of the T-cell repertoire in Omenn syndrome.Semantic proximity Read ↗

Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.Semantic proximity Read ↗

Omenn syndrome: a lack of tolerance on the background of deficient lymphocyte development and maturation.Semantic proximity Read ↗

Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation.Semantic proximity Read ↗

Omenn Syndrome Presenting with Striking Erythroderma and Extreme Lymphocytosis in a Newborn.Semantic proximity Read ↗

T-cell abnormalities are present at high frequencies in patients with hypereosinophilic syndromeSemantic proximity Read ↗

HyperIgE in hypomorphic recombination-activating gene defects.Semantic proximity Read ↗

[Analysis of genetic mutations and pathogenesis for two children with Omenn syndrome].Semantic proximity Read ↗

[Clinical phenotype and gene diagnostic analysis of Omenn syndrome].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.