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Article

A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM.

The Journal of clinical endocrinology and metabolism - 1 Jul 1998

Kao Y L, Donaghue K, Chan A, Knight J, Silink M

Abstract excerpt

Serum paraoxonase is a glycoprotein which binds to high-density lipoproteins (HDL) and may prevent oxidation of LDL by hydrolyzing lipid peroxides. Two polymorphisms identified in the paraoxonase gene (Met-Leu 54 and Gln-Arg 192) have been associated with cardiovascular disease. Oxidative low-density lipoprotein (LDL) is also toxic to retinal capillary endothelial cells and pericytes, so that mildly modified LDL...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9661650
DOI: 10.1210/jcem.83.7.5096

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM.PMID 9661650Read ↗

Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes.Semantic proximity Read ↗

Modulation by blood glucose levels of activity and concentration of paraoxonase in young patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy.Semantic proximity Read ↗

Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.Semantic proximity Read ↗

Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus.Semantic proximity Read ↗

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.Semantic proximity Read ↗

Gln-Arg192 polymorphism of paraoxonase 1 is associated with carotid intima-media thickness in patients of type 2 diabetes mellitus of Chinese.Semantic proximity Read ↗

Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration.Semantic proximity Read ↗

Paraoxonase (PON1) 55 and 192 polymorphism and its effects to oxidant-antioxidant system in turkish patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Are PON1 Q/R 192 and M/L 55 polymorphisms risk factors for diabetes complications in Turkish population?Semantic proximity Read ↗

Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.Semantic proximity Read ↗

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