Article
A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM.
The Journal of clinical endocrinology and metabolism - 1 Jul 1998
Kao Y L, Donaghue K, Chan A, Knight J, Silink M
Abstract excerpt
Serum paraoxonase is a glycoprotein which binds to high-density lipoproteins (HDL) and may prevent oxidation of LDL by hydrolyzing lipid peroxides. Two polymorphisms identified in the paraoxonase gene (Met-Leu 54 and Gln-Arg 192) have been associated with cardiovascular disease. Oxidative low-den...
Topics
- Adolescent
- Amino Acid Substitution
- Arginine
- Aryldialkylphosphatase
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Diabetic Retinopathy
- Esterases
- Female
- Genetic Variation
- Glutamine
- Humans
- Leucine
- Male
- Methionine