Article
Modulation by blood glucose levels of activity and concentration of paraoxonase in young patients with type 1 diabetes mellitus.
Metabolism: clinical and experimental - 1 Jun 2001
Kordonouri O, James R W, Bennetts B, Chan A, Kao Y L, Danne T, Silink M, Donaghue K
Abstract excerpt
Paraoxonase (PON) is a high-density lipoprotein (HDL)-associated esterase, which may prevent the transformation of low-density lipoproteins (LDL) into biologically active, atherogenic particles. PON concentration and activity are affected by PON1 gene polymorphisms and found to be altered in type 2 diabetes patients with retinopathy. We investigated serum PON concentration, in vitro activity and polymorphism at...
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