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Article

Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts.

International journal of cancer - 1 May 2006

Pallini Roberto, Sorrentino Antonio, Pierconti Francesco, Maggiano Nicola, Faggi Riccardo, Montano Nicola, Maira Giulio, Larocca Luigi Maria, Levi Andrea, Falchetti Maria Laura

Abstract excerpt

Telomerase is highly expressed in advanced stages of most cancers where it allows the clonal expansion of transformed cells by counteracting telomere erosion. Telomerase may also contribute to tumor progression through still undefined cell growth-promoting functions. Here, we inhibited telomerase activity in 2 human glioblastoma (GBM) cell lines, TB10 and U87MG, by targeting the catalytic subunit, hTERT, via...

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Source

Identifiers

PMID: 16331616
DOI: 10.1002/ijc.21613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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