Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

doi:10.1002/(sici)1097-0142(19980701)83:1<41::aid-cncr6>3.0.co;2-h

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Article

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

Cancer - 1 Jul 1998

Phillips W A, St Clair F, Munday A D, Thomas R J, Mitchell C A

Abstract excerpt

BACKGROUND: Phosphatidylinositol 3-kinase (PI 3-kinase), an enzyme that phosphorylates inositol phospholipids at the D-3 position of the inositol ring, has been implicated in the signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. In spi...

Topics

Colorectal Neoplasms
Genes, ras
Humans
Mutation
Phosphatidylinositol 3-Kinases
Phosphorylation

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