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Article

The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

Cellular and molecular life sciences : CMLS - 1 Jul 2002

Sauvage E, Kerff F, Fonzé E, Herman R, Schoot B, Marquette J P, Taburet Y, Prevost D, Dumas J, Leonard G, Stefanic P, Coyette J, Charlier P

Abstract excerpt

Penicillin-binding proteins (PBPs) are membrane proteins involved in the final stages of peptidoglycan synthesis and represent the targets of beta-lactam antibiotics. Enterococci are naturally resistant to these antibiotics because they produce a PBP, named PBP5fm in Enterococcus faecium, with low-level affinity for beta-lactams. We report here the crystal structure of the acyl-enzyme complex of PBP5fm with...

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Identifiers

PMID: 12222968
DOI: 10.1007/s00018-002-8500-0
PMCID: PMC11337508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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