Article
Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells.
European journal of cell biology - 1 May 1998
Thyberg J
Abstract excerpt
To proliferate, vascular smooth muscle cells first convert from a contractile to a synthetic phenotype. Earlier studies indicate that this process is supported by fibronectin and accelerated by platelet-derived growth factor (PDGF). Here, the mechanisms in this transition were further explored. I...
Topics
- Androstadienes
- Animals
- Cell Division
- Cells, Cultured
- Enzyme Inhibitors
- Golgi Apparatus
- Male
- Muscle, Smooth, Vascular
- Nitriles
- Phenotype
- Phosphoinositide-3 Kinase Inhibitors
- Rats
- Rats, Sprague-Dawley
- Receptor Protein-Tyrosine Kinases
- Receptors, Platelet-Derived Growth Factor
- Tyrphostins
- Wortmannin