Article
Phenotype modulation in primary cultures of aortic smooth muscle cells from streptozotocin-diabetic rats.
Differentiation; research in biological diversity - 1 Aug 1998
Etienne P, Parés-Herbuté N, Mani-Ponset L, Gabrion J, Rabesandratana H, Herbuté S, Monnier L
Abstract excerpt
Diabetes mellitus is a major risk factor for atherosclerosis. In atherosclerotic lesions, arterial smooth muscle cells (SMC) change from a contractile to a synthetic phenotype characterized by active proliferation. A similar phenotype modulation occurs in vitro when isolated arterial SMC are grow...
Topics
- Actins
- Animals
- Aorta, Thoracic
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Diabetes Mellitus, Experimental
- Flow Cytometry
- Kinetics
- Male
- Muscle, Smooth, Vascular
- Phenotype
- Rats
- Rats, Wistar
- Reference Values
- Time Factors