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Article

Phenotype modulation in primary cultures of aortic smooth muscle cells from streptozotocin-diabetic rats.

Differentiation; research in biological diversity - 1 Aug 1998

Etienne P, Parés-Herbuté N, Mani-Ponset L, Gabrion J, Rabesandratana H, Herbuté S, Monnier L

Abstract excerpt

Diabetes mellitus is a major risk factor for atherosclerosis. In atherosclerotic lesions, arterial smooth muscle cells (SMC) change from a contractile to a synthetic phenotype characterized by active proliferation. A similar phenotype modulation occurs in vitro when isolated arterial SMC are grown in culture and is characterized by both changes in cell morphology and a typical switch in actin isoform expression....

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PMID: 9745713
DOI: 10.1111/j.1432-0436.1998.00225.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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