Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Corrective Transduction of Human Epidermal Stem Cells in Laminin-5-Dependent Junctional Epidermolysis Bullosa

10 Jun 1998

Abstract excerpt

Laminin-5 is composed of three distinct polypeptides, α3, β3, and γ2, which are encoded by three different genes, LAMA3, LAMB3, and LAMC2, respectively. We have isolated epidermal keratinocytes from a patient presenting with a lethal form of junctional epidermolysis bullosa characterized by a homozygous mutation of the LAMB3 gene, which led to complete absence of the β3 polypeptide. In vitro, β3-null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Silk-based biomaterials and applications
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9650620
DOI: 10.1089/hum.1998.9.9-1359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Corrective Transduction of Human Epidermal Stem Cells in Laminin-5-Dependent Junctional Epidermolysis BullosaPMID 9650620Read ↗

In vivo restoration of laminin 5 β3 expression and function in junctional epidermolysis bullosaSemantic proximity Read ↗

CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient.Semantic proximity Read ↗

Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant.Semantic proximity Read ↗

Establishment and characterization of cell line LSV5 that retains the altered adhesive properties of human junctional epidermolysis bullosa keratinocytes.Semantic proximity Read ↗

Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosaSemantic proximity Read ↗

Toward epidermal stem cell-mediated ex vivo gene therapy of junctional epidermolysis bullosa.Semantic proximity Read ↗

Closure of a Large Chronic Wound through Transplantation of Gene-Corrected Epidermal Stem CellsSemantic proximity Read ↗

Alterations in the microenvironment of junctional epidermolysis bullosa keratinocytes: A gene expression studySemantic proximity Read ↗

Protein therapeutics for junctional epidermolysis bullosa: incorporation of recombinant beta3 chain into laminin 332 in beta3-/- keratinocytes in vitro.Semantic proximity Read ↗

Functional Re-expression of laminin-5 in laminin-gamma2-deficient human keratinocytes modifies cell morphology, motility, and adhesion.Semantic proximity Read ↗

Laminin 332 in junctional epidermolysis bullosaSemantic proximity Read ↗

Genetic bases of severe junctional epidermolysis bullosa presenting spontaneous amelioration with aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.