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Article

Closure of a Large Chronic Wound through Transplantation of Gene-Corrected Epidermal Stem Cells

10 Nov 2016

Abstract excerpt

Generalized junctional epidermolysis bullosa (JEB) is caused by mutations in LAMA3, LAMB3, or LAMC2, which together encode laminin-332, a heterotrimeric protein consisting of α3, β3, and γ2 chains (Fine et al., 2014). In nonlethal generalized intermediate JEB, laminin-332 is highly reduced, and hemidesmosomes are rudimentary or completely absent, leading to blister formation within the lamina lucida of the...

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PMID: 27840234
DOI: 10.1016/j.jid.2016.10.038

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