Article
Mutations and modifications support a 'pitted-flexiball' model for alpha-crystallin.
International journal of biological macromolecules - 1 Jan 2000
Smulders R H, van Boekel M A, de Jong W W
Abstract excerpt
alpha-Crystallin is renown for resisting crystallization and electron microscopic image analysis. The spatial conformation thus remaining elusive, the authors explored the structure and chaperone functioning by analyzing the effects of site-directed mutagenesis, the properties of naturally occurr...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cattle
- Crystallins
- Macromolecular Substances
- Models, Molecular
- Mole Rats
- Molecular Chaperones
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Protein Processing, Post-Translational
- Rats