Article
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry - 1 Jul 1998
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido T C, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, Ihara Y
Abstract excerpt
The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken b...
Topics
- Aged
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Brain Chemistry
- Cell Fractionation
- Gene Expression
- Humans
- Membrane Proteins
- Mice
- Mice, Transgenic
- Mutation
- Peptide Fragments