Article
Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.
Brain research. Molecular brain research - 23 Aug 2004
Smith Margaret J, Sharples Robyn A, Evin Geneviève, McLean Catriona A, Dean Brian, Pavey Geoff, Fantino Emmanuelle, Cotton Richard G H, Imaizumi Kazunori, Masters Colin L, Cappai Roberto, Culvenor Janetta G
Abstract excerpt
We have analysed the expression of a truncated variant presenilin 2 protein (PS2V) in frontal cortex from subjects with Alzheimer's disease (AD) and age-matched controls, and compared these results with cortex from bipolar disorder (BP), schizophrenia (SZ) and controls in a second brain bank collection. PS2V protein was detected as a 14 kDa species with antibodies directed to the PS2 N-terminal region and to the...
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