Article
Novel oncogenic mutations in the WT1 Wilms' tumor suppressor gene: a t(11;22) fuses the Ewing's sarcoma gene, EWS1, to WT1 in desmoplastic small round cell tumor.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 1994
Rauscher F J, Benjamin L E, Fredericks W J, Morris J F
Abstract excerpt
These studies suggest that the WT1 tumor suppressor gene, originally identified as a recessive oncogene in Wilms' tumors, is capable of sustaining a gain-of-function mutation which results in its contribution to a completely different disease entity: desmoplastic small round cell tumor. Two indep...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Differentiation
- Child
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 22
- Cloning, Molecular
- DNA Primers
- DNA, Neoplasm
- DNA-Binding Proteins
- Genes, Wilms Tumor
- Humans
- Kidney Neoplasms
- Molecular Sequence Data