Article
Detection of maternal DNA in umbilical cord blood by polymerase chain reaction amplification of minisatellite sequences.
Bone marrow transplantation - 1 Jun 1998
Briz M, Regidor C, Monteagudo D, Somolinos N, Garaulet C, Forés R, Posada M, Fernández M N
Abstract excerpt
One of the concerns about the use of cord blood as a source of hematopoietic stem cells for allogeneic transplantation is the possibility of contamination by maternal cells which could cause life-threatening GVHD. We have assessed cord blood contamination using PCR analysis of several minisatelli...
Topics
- Chimera
- DNA
- Female
- Fetal Blood
- Genotype
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Humans
- Infant, Newborn
- Maternal-Fetal Exchange
- Minisatellite Repeats
- Polymerase Chain Reaction
- Pregnancy
- Sensitivity and Specificity
- Transplantation, Homologous