Article
A molecular study of first and second RB1 mutational hits in retinoblastoma patients.
Cancer genetics and cytogenetics - 1 May 2006
de Andrade Ana Flávia Belchior, da Hora Barbosa Raquel, Vargas Fernando Regla, Ferman Sima, Eisenberg Ana Lúcia, Fernandes Luisa, Bonvicino Cibele R
Abstract excerpt
RB1 mutations accountable for biallelic inactivation are crucial events in the development of retinoblastoma because a first mutation (M1) predisposes to retinoblastoma while a second mutation (M2) is required for tumor development. Mutational analyses of this gene showed a wide spectrum of genetic alterations (single base substitutions, insertions, or deletions, as well as small and large deletions). The most...
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