Article
Reconstitution of EBV-specific T cell immunity in solid organ transplant recipients.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998
Haque T, Amlot P L, Helling N, Thomas J A, Sweny P, Rolles K, Burroughs A K, Prentice H G, Crawford D H
Abstract excerpt
EBV-specific autologous CTL were grown in vitro from three adults (two liver transplant recipients and one patient on hemodialysis awaiting kidney retransplant). All CTL lines were TCR alphabeta, CD8 positive cells, EBV specific, and MHC class I restricted. The CTL lines were expanded in vitro and infused in three escalating doses (5 x 10(7), 1 x 10(8), and 2 x 10(8) at monthly intervals. Weekly blood samples...
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