Article
Mutation analysis of the c-mos proto-oncogene in human ovarian teratomas.
British journal of cancer - 1 May 1998
de Foy K A, Gayther S A, Colledge W H, Crockett S, Scott I V, Evans M J, Ponder B A
Abstract excerpt
Female transgenic mice lacking a functional c-mos proto-oncogene develop ovarian teratomas, indicating that c-mos may behave as a tumour-suppressor gene for this type of tumour. We have analysed the entire coding region of the c-MOS gene in a series of human ovarian teratomas to determine whether there are any cancer-causing alterations. DNA from twenty teratomas was analysed by single-strand conformational...
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