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Article

Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2025

Chao Angel, Lai Chyong-Huey, Chao An-Shine, Lin Chiao-Yun, Wang You-Chen, Huang Huei-Jean, Wu Ren-Chin

Abstract excerpt

Squamous cell carcinoma (SCC) of the ovary, an uncommon form of gynecologic cancer, typically originates from the malignant transformation of a pre-existing mature ovarian teratoma (MOT). However, due to its rarity, the molecular pathways driving its development are not well understood. To address this knowledge gap, we performed molecular inversion probe (MIP) array analysis and targeted sequencing of 275 cancer...

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Identifiers

PMID: 39630279
DOI: 10.1007/s00109-024-02505-w

Genes

CDKN2A
MIP
TP53
KMT2D
PIK3CA
PTEN

Provenance

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