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Article

Disruption of the lama2 gene in embryonic stem cells: laminin alpha 2 is necessary for sustenance of mature muscle cells.

Experimental cell research - 25 May 1998

Kuang W, Xu H, Vachon P H, Engvall E

Abstract excerpt

Mutations in the gene coding for the alpha 2 chain of laminin-2 and -4 (merosin) cause a severe form of congenital muscular dystrophy in humans and mice. To establish a defined model for in vitro and in vivo studies of the role of laminin alpha 2/merosin in development and cell and tissue functio...

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Identifiers

PMID: 9633519
DOI: 10.1006/excr.1998.4025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9633519-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Disruption of the lama2 gene in embryonic stem cells: laminin alpha 2 is necessary for sustenance of mature muscle cells.PMID 9633519Read ↗

Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophySemantic proximity Read ↗

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms.Semantic proximity Read ↗

Deregulation of multiple mechanisms shapes the onset of <i>LAMA2</i> -congenital muscular dystrophySemantic proximity Read ↗

Current understanding and treatment of cardiac and skeletal muscle pathology in laminin-α2 chain-deficient congenital muscular dystrophySemantic proximity Read ↗

The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2-deficient congenital muscular dystrophy.Semantic proximity Read ↗

The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment.Semantic proximity Read ↗

Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosisSemantic proximity Read ↗

Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy.Semantic proximity Read ↗

Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies.Semantic proximity Read ↗

Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination.Semantic proximity Read ↗

Laminin-α2 Chain-Deficient Congenital Muscular Dystrophy: Pathophysiology and Development of Treatment.Semantic proximity Read ↗

A splice site mutation in laminin-α2 results in a severe muscular dystrophy and growth abnormalities in zebrafish.Semantic proximity Read ↗

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