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Article

The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment.

Development (Cambridge, England) - 1 Oct 2009

Jacoby Arie S, Busch-Nentwich Elisabeth, Bryson-Richardson Robert J, Hall Thomas E, Berger Joachim, Berger Silke, Sonntag Carmen, Sachs Caroline, Geisler Robert, Stemple Derek L, Currie Peter D

Abstract excerpt

The skeletal muscle basement membrane fulfils several crucial functions during development and in the mature myotome and defects in its composition underlie certain forms of muscular dystrophy. A major component of this extracellular structure is the laminin polymer, which assembles into a resilient meshwork that protects the sarcolemma during contraction. Here we describe a zebrafish mutant, softy, which...

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Share to Animals, Genetically Modified
Share to Basement Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophy, Animal

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Source

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Identifiers

PMID: 19736328
DOI: 10.1242/dev.034561
PMCID: PMC2739150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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