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Article

The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2-deficient congenital muscular dystrophy.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2007

Hall Thomas E, Bryson-Richardson Robert J, Berger Silke, Jacoby Arie S, Cole Nicholas J, Hollway Georgina E, Berger Joachim, Currie Peter D

Abstract excerpt

Mutations in the human laminin alpha2 (LAMA2) gene result in the most common form of congenital muscular dystrophy (MDC1A). There are currently three models for the molecular basis of cellular pathology in MDC1A: (i) lack of LAMA2 leads to sarcolemmal weakness and failure, followed by cellular ne...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophy, Animal

Share to Oligonucleotides, Antisense

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Source

Open in PubMed Open full text

Identifiers

PMID: 17438294
DOI: 10.1073/pnas.0700942104
PMCID: PMC1855385

Genes

LAMA2
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17438294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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