Article
Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.
Therapeutic drug monitoring - 1 Jun 1998
Kimura M, Ieiri I, Mamiya K, Urae A, Higuchi S
Abstract excerpt
Genotypings of two mutations (*2 and *3) in CYP2C19 and the amino acid variants (Arg144/Cys, Tyr358/Cys, Ile359/Leu, and Gly417/Asp) in CYP2C9 were carried out in 140 unrelated Japanese subjects. Thirty-three subjects (23.6%) were genotypically identified as poor metabolizers of CYP2C19, and the allele frequencies of the CYP2C19*2 and CYP2C19*3 were 0.35 and 0.11, respectively. The authors' findings are in...
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