Article
A structured, minimal parameter model of the central nitrogen metabolism in Saccharomyces cerevisiae: the prediction of the behavior of mutants.
Journal of theoretical biology - 21 Apr 1998
van Riel N A, Giuseppin M L, TerSchure E G, Verrips C T
Abstract excerpt
In order to enable future pathway engineering of a complex system, such as the nitrogen metabolism in yeast, mathematical modelling tools have to be developed. The stoichiometric and biochemical characteristics of the glutamate and glutamine nodes (the Central Nitrogen Metabolism, CNM) are qualitatively known. Quantitative knowledge about the dynamics of the network lacks and needs to be developed for metabolic...
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