Article
Analysis of a naturally occurring mutation in sucrase-isomaltase: glutamine 1098 is not essential for transport to the surface of COS-1 cells.
Biochimica et biophysica acta - 28 Apr 1998
Ouwendijk J, Peters W J, te Morsche R H, van de Vorstenbosch R A, Ginsel L A, Naim H Y, Fransen J A
Abstract excerpt
A glutamine for proline substitution at position 1098 was previously shown to result in accumulation of brush-border sucrase-isomaltase in the Golgi apparatus. The substitution is present in a highly homologous region of the protein, and results in a comparable accumulation when introduced into the same region in lysosomal alpha-glucosidase. To study the importance of the glutamine-1098, we analyzed the transport...
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