Article
Two alanines juxtaposed to aggrecan's G1 domain alter its intracellular localization.
Journal of cellular biochemistry - 15 Oct 2003
Oliver Bonnie L, Cronin Chunxia G, Bue Catherine, Hand Arthur R, Tanzer Marvin L
Abstract excerpt
Nascent proteins translated and processed in the endoplasmic reticulum (ER) sometimes contain intrinsic signals for ER retention or ER retrieval. These signals are usually a few amino acids in length, and if alanine modifications are made within these sequences, normal transit patterns of the nascent protein frequently change. The purpose of this study was to determine whether two alanines juxtaposed to the first...
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