CD40 and CD70 co-stimulate a potent in vivo antitumor T cell response.

Abstract excerpt

In several studies, CD80, a potent co-stimulatory molecule, has been reported to be responsible for the induction of CD8+ antitumor T cell responses by CD80-transfected tumor cells. However, expression of CD80 by tumors not always ensures generation of a T cell-mediated antitumor response. Variables such as the inherent immunogenicity of a tumor and its major histocompatibility complex (MHC) expression status...

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