Article
Coordinate transcription and physical linkage of domains in surfactin synthetase are not essential for proper assembly and activity of the multienzyme complex.
The Journal of biological chemistry - 5 Jun 1998
Guenzi E, Galli G, Grgurina I, Pace E, Ferranti P, Grandi G
Abstract excerpt
Bacterial peptide synthetases have two common features that appear to be strictly conserved. 1) The enzyme subunits are co-regulated at both transcriptional and translational level. 2) The organization of the different enzymatic domains constituting the enzyme fulfills the "colinearity rule" acco...
Topics
- Bacillus subtilis
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Lipoproteins
- Mass Spectrometry
- Mutation
- Open Reading Frames
- Operon
- Peptide Synthases
- Protein Biosynthesis
- Transcription, Genetic