Article
MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD.
Neurology - 14 May 2002
Hernán M A, Checkoway H, O'Brien R, Costa-Mallen P, De Vivo I, Colditz G A, Hunter D J, Kelsey K T, Ascherio A
Abstract excerpt
BACKGROUND: A polymorphism (G to A transition) in intron 13 of the mitochondrial enzyme monoamine oxidase B (MAOB) gene may modify, alone or by interacting with the catechol-O-methyltransferase (COMT(LL)) genotype (low enzymatic activity), the risk of idiopathic PD. Also, the association between never smoking and PD risk may be present only in people with the MAOB G allele. METHODS: The authors studied two...
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