Article
Differential inhibition of wild-type endothelin-converting enzyme-1 and its mutants.
Journal of cardiovascular pharmacology - 1 Jan 1998
Savage P, De Lombaert S, Shimada K, Tanzawa K, Jeng A Y
Abstract excerpt
The purpose of this study was to determine the effect of mutation of rat endothelin-converting enzyme-1 (ECE-1) on the potencies of various inhibitors. The two amino acids mutated were Cys(412), which was shown to link the two monomeric enzymes to form a dimer, and Glu(752), postulated to be involved in substrate and inhibitor binding. No significant effects were noted when Glu(752) was replaced by an acidic...
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