Article
Enhanced macrophage uptake of lipoprotein(a) after Ca2+-induced aggregate-formation.
Lipids - 1 Apr 1998
Tanaka S, Yashiro A, Tasaki H, Nakashima Y
Abstract excerpt
We tested the hypothesis that aggregated lipoprotein(a) [Lp(a)] is avidly taken up by macrophages. Lp(a) was isolated by sequential centrifugations and gel chromatography from a patient with high plasma levels of Lp(a) who was being treated with low density lipoprotein (LDL)-apheresis. Aggregated Lp(a) was prepared by mixing native Lp(a) with 2.5 mmol/L CaCl2, and 54% of the 125I-Lp(a) aggregated after...
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