Article
Heparin extracorporeal LDL precipitation (HELP): an effective apheresis procedure for lowering Lp(a) levels.
Chemistry and physics of lipids - 1 Jan 1994
Armstrong V W, Schuff-Werner P, Eisenhauer T, Helmhold M, Stix M, Seidel D
Abstract excerpt
Heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) is based on the precipitation of apolipoprotein B (apo B) containing lipoproteins with heparin at low pH (4.85). In in vitro experiments we could show that Lp(a) is quantitatively (> 99%) precipitated from plasma by heparin in the pH range 4.6-5.2. The acute changes in Lp(a) after a single HELP-LDL apheresis were investigated in twelve...
Topics
- Apolipoproteins
- Apoprotein(a)
- Arteriosclerosis
- Blood Component Removal
- Chemical Precipitation
- Cholesterol, LDL
- Heparin
- Humans
- Hydrogen-Ion Concentration
- Hyperlipoproteinemia Type II
- Kinetics