Article
Determinants of lipoprotein(a) assembly: a study of wild-type and mutant apolipoprotein(a) phenotypes isolated from human and rhesus monkey lipoprotein(a) under mild reductive conditions.
Biochemistry - 19 Dec 1995
Edelstein C, Mandala M, Pfaffinger D, Scanu A M
Abstract excerpt
We previously observed that rhesus monkey lipoprotein(a) [Lp(a)], is lysine-binding defective (Lys-) and attributed this deficiency to the presence of Arg72 in the lysine-binding site (LBS) of kringle IV-10 of apolipoprotein(a) [apo(a)] [Scanu, A.M., Miles, L.A., Fless, G.M., Pfaffinger, D., Eise...
Topics
- Aminocaproates
- Animals
- Apolipoproteins A
- Binding Sites
- Blotting, Western
- Chromatography, Gel
- Circular Dichroism
- Female
- Humans
- Kringles
- Lipoprotein(a)
- Lipoproteins, LDL
- Lysine
- Macaca mulatta
- Male
- Models, Molecular
- Mutation
- Oxidation-Reduction