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Influence of Comorbid Psychiatric Disorders on the Risk of Development of Alcohol Dependence by Genetic Variations of ALDH2 and ADH1B.

Alcoholism, clinical and experimental research - 1 Nov 2020

Itoh Mitsuru, Yonemoto Tomoko, Ueno Fumihiko, Iwahara Chie, Yumoto Yosuke, Nakayama Hideki, Maesato Hitoshi, Kimura Mitsuru, Matsushita Sachio

Abstract excerpt

BACKGROUND: Inactive aldehyde dehydrogenase-2 (ALDH2) is a well-known deterrent to the development of alcohol use disorder (AUD), and however, some individuals with inactive ALDH2 do go on to develop AUD. These alcoholics are likely to have strong risk factors for the development of this disorder. Using a model of alcoholics with inactive ALDH2 (the AIA model), we investigated the unique characteristics of...

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PMID: 32890420
DOI: 10.1111/acer.14450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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