Article
[Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure].
Nihon Jinzo Gakkai shi - 1 Jul 1998
Kuriyama S, Suzuki Y, Atsumi Y, Tomonari H, Matsuoka K, Houjou T, Shoji R, Hosoya T
Abstract excerpt
In order to investigate the influence of aldehyde dehydrogenase 2(ALDH2) genotype in the pathogenesis of nephropathy due to non-insulin dependent diabetes mellitus (NIDDM), genotyping of ALDH2 was measured using the PCR-RFLP method in patients with NIDDM on chronic hemodialysis (HD). The results were as follows; 1) The frequency of active ALDH2 was 63% and that of inactive ALDH2 was 37%. 2) The percentage of...
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