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Article

Maternal meiosis I non-disjunction of chromosome 15: dependence of the maternal age effect on level of recombination

1 Jun 1998

Abstract excerpt

Non-disjoined chromosomes 15 from 115 cases of uniparental disomy (ascertained through Prader-Willi syndrome) and 13 cases of trisomy of maternal origin were densely typed for microsatellite loci spanning chromosome 15q. Of these 128 cases a total of 97 meiosis I (MI) errors, 19 meiosis II (MII) errors and 12 mitotic errors were identified. The genetic length of a map created from the MI errors was 101 cM, as...

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PMID: 9580665
DOI: 10.1093/hmg/7.6.1011

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