Article
Analysis of the insulin receptor gene tyrosine kinase domain in obese patients with hyperandrogenism, insulin resistance and acanthosis nigricans (type C insulin resistance).
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Apr 1998
Globerman H, Karnieli E
Abstract excerpt
OBJECTIVE: To test the hypothesis that the triad of hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome) in the presence of obesity, also known as type C insulin resistance (type C), is caused by mutations at the tyrosine kinase domain of the insulin receptor gene. DES...
Topics
- Acanthosis Nigricans
- Base Sequence
- Cohort Studies
- DNA Primers
- Fasting
- Female
- Glucose Clamp Technique
- Humans
- Hyperandrogenism
- Insulin
- Insulin Resistance
- Male
- Mutation
- Obesity
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptor, Insulin
- Syndrome