Article
Genetic analysis of the insulin receptor gene in Chinese patients with extreme insulin resistance.
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed - 1 Nov 1998
Lee W J, Sheu W H, Shu S G, Yao Y E
Abstract excerpt
BACKGROUND: Many patients with extreme insulin resistance in combination with acanthosis nigricans are reported to have defective insulin receptor genes. Because acanthosis nigricans is commonly accompanied by severe hyperinsulinemia and obesity, and obesity is a major factor in insulin resistance, this study was initiated to assess the prevalence of mutations in the insulin receptor gene in Chinese patients with...
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