Article
Phenotype 2 of deoxyribonuclease I may be used as a risk factor for gastric carcinoma.
Cancer - 1 May 1998
Tsutsumi S, Asao T, Nagamachi Y, Nakajima T, Yasuda T, Kishi K
Abstract excerpt
BACKGROUND: Human deoxyribonuclease I (DNase I) (EC3.1.21.1) is one of the candidate nucleases that acts in mammalian cells during apoptosis. Genetic polymorphism of DNase I has been classified into 15 phenotypes controlled by 5 autosomal codominant alleles. The purpose of this study was to determine whether DNase I polymorphism is closely related to the incidence of gastric carcinoma. METHODS: The phenotype...
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