Article
Two deoxyribonuclease I gene polymorphisms and correlation between genotype and its activity in Japanese population.
Legal medicine (Tokyo, Japan) - 1 Sept 2007
Fujihara Junko, Takatsuka Hisakazu, Kataoka Kaori, Xue Yuing, Takeshita Haruo
Abstract excerpt
Deoxyribonuclease I (DNase I) plays important roles for DNA fragmentation and degradation during programmed cell death. The single nucleotide polymorphism (SNP) at DNase I, designated as DNASE1, in exon 8 (A2317G) is considered to be one of the susceptibility genes for gastric and colorectal carcinoma and myocardial infarction. Recent research has shown the presence of a novel 56-bp variable number of tandem...
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