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Article

Endothelin-induced Apoptosis of A375 Human Melanoma Cells

1 May 1998

Abstract excerpt

Endothelin-1 (ET-1) inhibited serum-dependent growth of asynchronized A375 human melanoma cells, and the growth inhibitory effect was markedly enhanced when ET-1 was applied to the cells synchronized at G1/S boundary by double thymidine blocks. Flow cytometric analysis revealed that ET-1 did not inhibit the cell cycle progression after the release of the block but caused a significant increase of the hypodiploid...

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PMID: 9575219
DOI: 10.1074/jbc.273.20.12584

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