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Antibodies Targeting Human Endothelin-1 Receptors Reveal Different Conformational States in Cancer Cells

6 May 2018

Abstract excerpt

The endothelin axis (endothelins and their receptors) is strongly involved in physiological and pathological processes. ET-1 plays a crucial role in particular in tumor diseases. Endothelin-1 receptors (ET(A) and ET(B)) are deregulated and overexpressed in several tumors such as melanoma and glioma. We studied the binding of 24 monoclonal antibodies directed against human ET(B) receptors (hET(B)) to different...

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PMID: 29947545
DOI: 10.33549/physiolres.933848

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