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Article

Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents.

Experimental biology and medicine (Maywood, N.J.) - 1 Jun 2006

Berger Yann, Bernasconi Catherine Chapuis, Juillerat-Jeanneret Lucienne

Abstract excerpt

Endothelin (ET)-1 is an autocrine/paracrine growth factor or an antiapoptotic factor in human cancers, and blockade of ET-1 receptors can sensitize human tumor cells to apoptosis. The role of the ET-1 axis in the proliferation and/or apoptosis of melanoma cells and in their response to the alkylating agent, dacarbazine (DTIC), used in clinical treatment of human melanoma were investigated in five human melanoma...

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PMID: 16741059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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