Article
Bromodeoxyuridine-induced expression of endothelin A in A375 human melanoma cells.
Biochemical and biophysical research communications - 19 May 1997
Ohtani T, Ninomiya H, Okazawa M, Imamura S, Masaki T
Abstract excerpt
Expression of endothelin (ET) receptor subtypes was examined in an experimental model of A375 human melanoma cell differentiation using the pyrimidine analog bromodeoxyuridine (BUdR). BUdR (10 microM)-treated cells had an increased surface area and an increased dendricity, were contact-inhibited...
Topics
- Animals
- Bromodeoxyuridine
- Calcium
- Cell Differentiation
- Endothelin-1
- Gene Expression
- Humans
- Melanocytes
- Melanoma
- Mice
- Mice, Nude
- Models, Biological
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- Receptor, Endothelin A
- Receptors, Endothelin
- Tumor Cells, Cultured