Article
Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor.
Genes & development - 1 May 1998
Duncan D M, Burgess E A, Duncan I
Abstract excerpt
We report the molecular characterization of the spineless (ss) gene of Drosophila, and present evidence that it plays a central role in defining the distal regions of both the antenna and leg. ss encodes the closest known homolog of the mammalian dioxin receptor, a transcription factor of the bHLH-PAS family. Loss-of-function alleles of ss cause three major phenotypes: transformation of distal antenna to leg,...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Biological Evolution
- Chromosome Mapping
- Cloning, Molecular
- DNA, Complementary
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Genes, Insect
- Humans
- Insect Proteins
- Male
- Molecular Sequence Data
- Mutation
- Phenotype