Article
Bowl is required downstream of Notch for elaboration of distal limb patterning.
Development (Cambridge, England) - 1 Dec 2003
de Celis Ibeas Jesus M, Bray Sarah J
Abstract excerpt
In the Drosophila leg, activation of Notch leads to the establishment of the joints that subdivide the appendage into segments. We find that mutations in bowl result in similar phenotypes to Notch, causing fusion and truncations of tarsal segments (tarsomeres) and, like its close relative Odd-skipped, Bowl is produced in response to Notch signalling at a subset of segment boundaries. However, despite the fact...
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